Various factors can weaken cognitive abilities, affect your mood, and negatively affect the overall brain health. Fortunately, we have a wide array of options to use in order to improve brain function and boost cognitive skills. Nootropics have become a popular solution for many students, businesspeople, and basically, everyone else who wants to improve brain health. Coluracetam is one of many nootropics that people use regularly and in this post, you’re going to learn more about this cognitive enhancer and its benefits.

Coluracetam Overview

Coluracetam is a nootropic from the racetam family with a code name BCI-540, formerly MKC-231. The drug was originally studied by Mitsubishi Tanabe Pharma Corporation in Japan during the mid-90s for the treatment of Alzheimer’s disease. Although the studies showed the drug’s potential to repair learning and memory in mice with damaged nerve cells, there is no published research about the influence of coluracetam on Alzheimer’s disease treatment.

Coluracetam is, basically, a dietary supplement derived from piracetam. Since the nootropic failed to provide desired results in trials regarding Alzheimer’s disease, it was in-licensed by the company called BrainCells Inc. for the purpose of exploring its effects on treatment of depression. In the United States, coluracetam is easily available as a dietary supplement. Users have the opportunity to order it online without a doctor’s prescription.

How Does it Work?

Coluracetam has a unique mechanism of action due to the fact it works by improving choline uptake in the nerve cells through the choline uptake system (HACU). Why is this such a big deal? Well, this is the only choline uptake enhancer known to exist at this point. The choline uptake system elevates the concentration of acetylcholine in the brain. What many people don’t know is that coluracetam has the potential to restore this choline uptake system after nerve cell damage.

In addition to improving choline uptake, coluracetam also works to protect NMDA receptors against glutamate toxicity. It’s useful to mention now that the damage to these receptors takes part in brain diseases, Alzheimer’s disease, stroke, and other conditions. Even though coluracetam is an interesting nootropic and many scientists are exploring it now, we still need more studies in order to elucidate the full potential of the drug and maybe some other mechanisms of action.

What are the Benefits?

Coluracetam is a truly powerful nootropic that many people take for a wide array of purposes. As mentioned above, scientists find this cognitive enhancer interesting due to its unique mechanism of action, but the reality is that we need more studies that would confirm its health benefits. Below, we're going to take a closer look at the most important benefits that you can obtain with the regular use of coluracetam.


  • 1. Increases Memory

  • The number one reason why people buy nootropics is to improve their memory and coluracetam is not the exception. Users who purchase the cognitive enhancer expect it to sharpen their ability to recall information and take their memory to a whole new level. Some cognitive enhancers don’t work, but coluracetam does. For example, a study from the Journal of Neural Transmission found that coluracetam successfully addressed and improved memory deficits. This means that regular intake of this nootropic can, indeed, help you sharpen your memory and allow you to recall information more effectively. It goes without saying how much this is important for school, work, or basically everything else.

  • 2. Improves Learning

  • Your learning ability never remains constant; just like overall cognitive skills, it goes up and down. When learning decreases, it becomes difficult to perform problem-solving skills, take part in decision-making, recall information, among other things. We can easily say that decreased learning skills have a negative impact on your quality of life. Coluracetam proves to be effective for improving learning by elevating acetylcholine levels in addition to strengthening memory.

  • 3. Reduces Depression and Anxiety

  • Bearing in mind that millions of people around the globe struggle with anxiety and depression it has never been more important to have an effective agent that will help alleviate symptoms of these conditions. Even more so if that particular treatment agent is available as a dietary supplement! Coluracetam shows a tremendous potential to help people who have anxiety and depression. It is theorized that the mechanism of action through which coluracetam treats depression is through decreased glutamate toxicity. Also, evidence shows that regular intake of coluracetam for 21 days led to a 20% improvement in symptoms of anxiety. For comparison sake, valium had only 16% effect.

  • 4. Promotes Neurogenesis

  • Neurogenesis is defined as the process through which neurons are generated from neural stem cells. Basically, neurogenesis is the creation of new brain cells, and this process is crucial for brain function and strong cognitive abilities. One of the most important benefits of coluracetam is its ability to promote neurogenesis. However, the underlying mechanism of action through which this nootropic supports the production of new brain cells is unknown but it could be related to the increase in hippocampal acetylcholine.


  • 5. Improves Vision

  • A common belief is that nootropics such as coluracetam are only good for memory and concentration, but they can do so much more than that. Remember, the brain is the center for all functions that you do including senses that you use on a daily basis. Therefore, it also regulates vision, hearing, and you name it. You'll be happy to know that coluracetam promotes nerve growth in degenerative disease affecting the retina. As a result, it can improve your vision which is yet another reason to consider taking this nootropic.

    Suggested Dosages

    Just like many other nootropics, particularly from the racetam family, the specific optimal dosage of coluracetam is unknown. However, there are a few indications about the possible dosage that yields health benefits associated with this nootropic. Taking a dosage of 3.2mg to is recommended, but the starting dose that many people take is 20mg.

    Based on some recommendations the average human may want to consider taking 2.5mg to 3mg coluracetam per each kilogram of body weight. More precisely, an average adult user should take about 200mg coluracetam a day. Doses ranging from 10mg to 80mg three times a day, totaling 240mg daily, did not show side effects in some people. Of course, one should never start taking a high dose of coluracetam first. It’s always better to start with the lowest dose and gradually increase it. To avoid potential risks, make sure you consult your healthcare provider about this subject.

    Many people dose coluracetam sublingually in order to avoid the first-pass metabolism in the intestinal tract. If you decide to use a sublingual solution, then it’s practical to start with a 20mg dose that you’ll take with a dropper. Place dropper under the tongue and hold for a few moments prior to swallowing. The longer the solution is there, the easier it will be for the body to absorb it.

    Another thing to bear in mind is that the dose of coluracetam peaks about 30 minutes after ingestion. Due to the fact it’s a fast-acting nootropic, you may want to time your dose in order to take the drug that will exhibit its effects right at the moment of rigorous mental work when you need it the most. Coluracetam levels in the bloodstream decline three hours or so after ingestion.

    Possible Side Effects

    Coluracetam is considered safe for general consumption, and the risk of side effects is very low. However, just like other nootropics and medications, it can be associated with some adverse reactions. When side effects are involved, they usually include:

    • Brain fog
    • Suicidal thoughts
    • Low mood
    • Irritability
    • Nausea
    • Changes in sleep pattern

    Remember, the above-mentioned side effects are rare. To reduce the risk of unfortunate scenarios you need to be careful about the dosage. Never take too much and always stick to the recommended values or the dose that manufacturer specified on the packaging.

    Overall Summary

    Coluracetam is more than “yet another” nootropic from the racetam family. This cognitive enhancer has a unique mechanism of action, exhibits strong effects, and it’s safe. Besides memory and learning, this nootropic can also improve your vision and promote emotional and mental health and wellbeing.


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